- Model NO.: CAS: 111-30-8
- Certification: WQA, REACH, SGS
- Color: White
- Type: Oil / Water Separation Agent
- Molecular Formula: C5h8o2
- Trademark: Hugestone
- Origin: Jiangsu
- Acid-Base Property: Alkaline Surface Disposal Agent
- Environmental Protection: Yes
- Appearance: Powder
- CAS Number: 111-30-8
- Einecs: 203-856-5
- Specification: USP
- HS Code: 29121900
A glutaraldehyde solution of 0.1% to 1.0% concentration may be used for system disinfection and as a preservative for long term storage. Glutaraldehyde is used in biological electron microscopy as a fixative. It kills cells quickly by crosslinking their proteins and is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.
Another example of an application for treatment of proteins with glutaraldehyde is the inactivation of bacterial toxins to create toxoid vaccines, e. G., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.
In a related application, glutaraldehyde is sometimes employed in the tanning of leather.
Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker. The oligomeric state of proteins can be examined through this application. Glutaraldehyde is also used in SDS-PAGE to fix proteins and peptides prior to staining. Typically, a gel is treated with a 5% solution for approximately half an hour, after which it must be thoroughly washed to remove the yellow stain brought about by reacting with free tris.
A solution of 10% w/w glutaraldehyde is sold under the name "Diswart Solution" to remove common and plantar warts. Product claims include: "Inactivates viruses and bacteria. Dries the wart surface. Stains the area treated brown, but will not harm the surrounding skin. "
Hydraulic Fracturing (Fracking) Fluid
Glutaraldehyde has been listed as a component of hydraulic fracturing "fracking" fluid. It is included in the additive called Alpha 1427, as a biocide, according to Material Safety Data Sheets released to the Morgantown Utility Board by Northeast Natural Energy. Bacterial growth can impair the production of oil and gas wells, and can be introduced into the formation from various sources including the source water, proppant, and polymer used in the hydraulic fracturing process. Glutaraldehyde is pumped as a liquid additive with the fracturing fluid to reduce or eliminate this source of formation and fracture conductivity damage.
Glutaraldehyde is an ingredient in a popular product for freshwater aquariums as a source of bioavailable organic carbon used by aquatic plants.
UN 2810 6.1/PG 2.
|Appearance||Pale yellow transparent liquid|
|pH at 25º C||3.0-5.0|
|Color (Pt-Co)||100 max|