Product Description
Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. It is a natural substance found in many plants.
Coumarin is used in certain perfumes and fabric conditioners. Coumarin has been used as an aroma enhancer in pipe tobaccos and certain alcoholic drinks, although in general it is banned as a flavorant food additive, due to concerns regarding its hepatotoxicity in animal models.
Coumarin was first synthesized in 1868. It is used in the pharmaceutical industry as a precursor reagent in the synthesis of a number of synthetic anticoagulant pharmaceuticals similar to dicoumarol, the notable ones being warfarin (brand name Coumadin) and some even more potent rodenticides that work by the same anticoagulant mechanism. Coumarins are a type of vitamin K antagonists. Pharmaceutical coumarins were all developed from the study of sweet clover disease; see warfarin for this history.
Coumarin has clinical medical value by itself, as an edema modifier. Coumarin and other benzopyrones, such as 5,6-benzopyrone, 1,2-benzopyrone, diosmin, and others, are known to stimulate macrophages to degrade extracellular albumen, allowing faster resorption of edematous fluids. Other biological activities that may lead to other medical uses have been suggested, with varying degrees of evidence.
Coumarin is also used as a gain medium in some dye lasers, and as a sensitizer in older photovoltaic technologies.
Medical use
Coumarins have shown some evidence of biological activity, but they are approved for few medical uses as pharmaceuticals. It is used in the treatment of asthma and lymphedema.
Product Name:
Coumarin
Synonyms:
TIMTEC-BB SBB000094;O-HYDROXYCINNAMIC ACID LACTONE;TONKA BEAN CAMPHOR;5,6-BENZO-2-PYRONE;AKOS 212-75;2H-1-BENZOPYRAN-2-ONE;2H-1-BENZOPYAN-2-ONE;1,2-BENZOPYRONE
CAS:
91-64-5
MF:
C9H6O2
MW:
146.14
EINECS:
202-086-7
Chemical Properties
WHITE CRYSTALS OR CRYSTALLINE POWDER
Usage
Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.
Usage
antineoplastic, antiinflammatory, antihyperglycaemic
General Description
Colorless crystals, flakes or colorless to white powder with a pleasant fragrant vanilla odor and a bitter aromatic burning taste.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Coumarin is sensitive to exposure to light. Coumarin is also sensitive to heat. Coumarin is incompatible with strong acids, strong bases and oxidizers. Coumarin is hydrolyzed by hot concentrated alkalis. Coumarin can be halogenated, nitrated and hydrogenated (in the presence of catalysts).
Health Hazard
SYMPTOMS: Exposure to Coumarin may cause narcosis. It may also cause irritation and liver damage.
Fire Hazard
Coumarin is combustible
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